Miniature In Vitro Dissolution Testing of Powders for Inhalation
نویسندگان
چکیده
منابع مشابه
Modeling dissolution of sparingly soluble multisized powders.
The dissolution of powder drugs, besides being a topic of utmost importance, especially for the sparingly soluble ones, is far from being well-explained. The purpose of the present study is, on the one hand, to obtain experimental dissolution profiles and, on the other hand, to analyze and process the data for dissolution modeling. Three different size fractions of a widely used sparingly solub...
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The aim of this research project was to investigate a potential standardized test method to characterize the dissolution properties of numerous formulation types available for pulmonary delivery. A commercially available dissolution tester was adapted for use as a testing apparatus by the incorporation of a membrane-containing holder. The holder was designed to enclose previously air-classified...
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A series of placebo powders for inhalation was characterized regarding bulk density and powder flowability using different techniques. The powders were of the ordered mixture type and were prepared by mixing a pharmaceutical carrier grade of lactose with different fractions of intermediate sized and fine (i.e., micronized) lactose. A modified Hausner Ratio was obtained by measurement of the pou...
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The effects of excipient crystallinity and water content on the physical stability of salmon calcitonin (sCT) in a spray-dried powder for inhalation have been investigated. sCT was dissolved in water with and without mannitol and then spray dried using a Büchi 190 spray dryer. The spray dried powders were stored for 5 days at 0, 29, 51, 58, 69, and 84% relative humidity at ambient temperature. ...
متن کاملDissolution Testing of
h o l l e n be c k @ u p m i n c. co m Raafat Fahmy1, William Marnane1 and Dennis Bensley, Jr.1 , R. Gary Hollenbeck*2 1Division of Manufacturing Technologies, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD 2Associate Professor, Department of Pharmaceutical Sciences, University of Maryland School of Pharmac y and Vice President,...
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ژورنال
عنوان ژورنال: Dissolution Technologies
سال: 2015
ISSN: 1521-298X
DOI: 10.14227/dt220315p40